The 10 Enzymes of Glycolysis

We’re the ten best friends that anyone could have, and we’ll never ever ever ever ever leave each other (unless something bad like denaturation happens).

Glucose, C6H12O6, can be considered as “fuel” for cells, serving as an energy (ATP) source, as seen in the equation down below. The energy from glucose can be obtained either by burning it (e.g. burning icing sugar), or through controlled oxidation reactions (glycolysis, the Krebs/TCA/citric acid cycle, and oxidative phosphorylation). 

C6H12O6 + 6O2 → 6CO2 + 6H2O + energy

The (beautifully coloured) images shown above are the majestic 10 enzymes used in glycolysis, a metabolic pathway that breaks down 1 molecule of glucose into 2 molecules of pyruvate, yielding a net production of 2 molecules of ATP (as well as 2NADH, 2H+, and 2H2O). The above photos are from the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB).

From left to right, and in the order they are seen in the 10 steps of glycolysis, the enzymes are: 

  1. Hexokinase
  2. Phosphohexose isomerase
  3. Phosphofructokinase-1
  4. Aldolase
  5. Triose phosphate isomerase
  6. Glyceraldehyde-3-phosphate dehydrogenase
  7. Phosphoglycerate kinase
  8. Phosphoglycerate mutase
  9. Enolase
  10. Pyruvate kinase

Head on over to the RCSB PDB to read more about the structure and function of each enzyme!

Source Used: RCSB PDB. Glycolytic Enzymes. (accessed June 13, 2013)


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